Explore the Metabolome.
Accelerate your discovery.

For 23 years, HMT has pioneered capillary electrophoresis-mass spectrometry (CE-MS) to provide the highest resolution and coverage of polar metabolites for biomarker discovery and cellular biology research.

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Why Metabolomics

Metabolomics turns the small molecules of cellular activity into measurable, actionable biology.

Closest to biological reality
Metabolites are the end-products of gene expression, protein activity, and environmental exposure. They reflect what is actually happening inside a cell or organism — not just its genetic potential.
Sensitive to change
Metabolite concentrations shift within minutes of a biological perturbation — drug treatment, disease onset, dietary change. No other omics layer responds as rapidly or directly.
Bridges all omics
Metabolomics integrates the cumulative output of genomics, transcriptomics, and proteomics into a single, actionable biochemical profile. It is the essential connector in any multi-omics study.
Growing field, growing impact
Publications involving metabolomics have grown 10-fold in the past decade, spanning oncology, neuroscience, cardiovascular disease, diabetes, gut microbiome research, food science, and fermentation.
Why HMT

A niche platform suite that no other metabolomics CRO offers

Over 23 years HMT has built a tightly focused portfolio of CE-MS and LC-MS capabilities — each addressing a specific analytical problem that standard platforms cannot solve. Below are the capabilities that set us apart.

Glc-1-P Glc-6-P isomers resolved ATP ADP Migration Time → CE-MS Electropherogram — Polar Metabolite Space Resolving isomers that LC-MS cannot distinguish · 7 orders of magnitude dynamic range sugar-phosphate isomers
CE-MS resolves structural isomers — such as glucose-1-phosphate and glucose-6-phosphate — that co-elute on standard LC columns. This specificity is the foundation of everything HMT does.
01
True untargeted discovery: OMEGA Scan Advanced + OMEGA Search
The OMEGA Scan Advanced option goes beyond annotated libraries — delivering unannotated spectral features and tentatively assigned metabolites, including small peptides in the mass 100–1,000 range (2-mers to 5-mers). Combined with the OMEGA Search pipeline, this provides a genuine route to novel biomarker discovery for metabolites not yet catalogued in public databases.
02
Quantitative energy metabolism: C-SCOPE, Q110 & Q353
Our C-SCOPE panel delivers absolute quantitation of 116 metabolites spanning glycolysis, the TCA cycle, pentose phosphate pathway, amino acids, and urea cycle — purpose-built for cancer metabolism, Warburg effect, and mitochondrial function studies. The Q110 and Q353 panels extend quantitation to 110 or 353 polar metabolites respectively, and can be customised with client-specified metabolites of interest.
03
Mid-molar peptidomics: a patented platform no one else offers
Separate from OMEGA Scan, HMT's Peptidomics platform uses a patented approach to identify and profile small intact proteins and bioactive peptide fragments in the mass 1,000–10,000 range — a space inaccessible to standard metabolomics or conventional proteomics. Applications include hormone profiling, natriuretic peptides, amyloid fragments, and novel bioactive peptide discovery in neurology, nephrology, metabolic disease, and cancer. Currently available on serum and plasma.
04
Metabolic flux analysis with ¹³C and ¹⁵N labelling (F-SCOPE)
F-SCOPE is a targeted isotopomer panel covering 54 polar metabolites in glycolysis, the TCA cycle, purines, pyrimidines, urea cycle, and amino acids. It measures C13 and N15 heavy-atom labelled metabolite transformations for in-vivo flux analysis of glucose oxidation and glutamine metabolism — and is expandable to include client-specific metabolites not in the standard panel.
05
Custom panel development and fit-for-purpose assays
HMT develops bespoke quantitative assays using CE-MS and LC-MS, validated for research or clinical use. Whether you need to extend an existing panel with your metabolites of interest, or build a new assay from scratch for a Phase 2/3 clinical study, we design and validate the method with you. No other metabolomics CRO offers this level of analytical customisation.
06
Free scientific interpretation included with every study
Every HMT report includes pathway mapping, PCA, HCA, and statistical analysis — and follow-up discussion with an experienced biochemist is standard, not a paid add-on. We help you connect your metabolomics data to your biology: linking findings to RNA-seq, 16S sequencing, cytokine data, clinical parameters, or drug regimens as needed.
>1,000 Energy Metabolites Quantified (C-SCOPE, Q110, Q353)
>1,000 Publications Using HMT Technology
>1,000 Metabolites Per Sample · OMEGA Advanced
Find Your Platform

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The Process

From sample to insight

HMT's end-to-end workflow is designed to minimise your effort and maximise data quality — from shipment to a final biological interpretation report.

01
Consultation & Platform Selection
Our scientists review your study design, sample type, and research goal to recommend the optimal platform combination.
Typically 1–2 business days
02
Sample Shipment & Preparation
You ship frozen samples (dry ice) to our Boston facility. We handle extraction and QC according to validated SOPs. Sample prep guidelines provided on request.
Samples received within 1–2 days
03
CE-MS / LC-MS Analysis
Samples run on our CE-TOFMS and HPLC-FTMS systems with full QC monitoring. Each batch includes internal standards, blanks, and pooled QC samples.
2–4 weeks depending on platform
04
Data Delivery & Scientific Interpretation
You receive your data plus a comprehensive report with pathway maps, statistical analysis, and biochemist review. Follow-up discussions are standard practice, not an add-on.
Full report within 1 week of analysis
Scientific Validation

Trusted by leading researchers

HMT platforms have supported peer-reviewed publications across oncology, neuroscience, diabetes, cardiovascular disease, gut microbiome research, and more.

PNAS · 2015
L-cysteine reversibly inhibits glucose-induced biphasic insulin secretion and ATP production by inactivating PKM2
Nakatsu D. et al.
OMEGA ScanCells
Cell · 2019
Host-Microbe-Drug-Nutrient Screen Identifies Bacterial Effectors of Metformin Therapy
Pryor R. et al.
CE-MSGut Microbiome
EMBO Mol Med · 2019
Alternative oxidase-mediated respiration prevents lethal mitochondrial cardiomyopathy
Rajendran J. et al.
OMEGA ScanTissue
J. Gastroenterology · 2013
Serum metabolomic profile and potential biomarkers for severity of fibrosis in nonalcoholic fatty liver disease
Tokushige K. et al.
CE-MSSerum
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