C-SCOPE — 116 Glycolytic Metabolites
quantified with CE-MS precision

C-SCOPE is HMT's targeted quantitative glycolytic panel — 116 glycolytic metabolites measured with absolute concentrations using CE-MS. The panel spans glycolysis, the pentose phosphate pathway, TCA cycle, amino acids, and the urea cycle, providing a comprehensive biochemical picture of central carbon and energy metabolism.

C-SCOPE is most commonly used as a standalone panel for cellular metabolism studies, particularly in cancer research where the Warburg effect, mitochondrial dysfunction, and metabolic reprogramming are under investigation. It can also be combined with OMEGA Scan for broader untargeted coverage in the same study.

Many glycolytic intermediates are structural isomers — glucose-1-phosphate vs glucose-6-phosphate, ribose-5-phosphate vs ribulose-5-phosphate, and others — that are indistinguishable by LC-MS. CE-MS separation resolves these isomers as distinct analytes, eliminating a systematic source of misidentification that affects glycolytic panel data on competing platforms.